Manchester United beat Crystal Palace 2-1 to go third in the Premier League, while Tottenham failed to dispel relegation fears after defeat at Fulham.
Sesko was handed his first start in seven games since Michael Carrick took charge at Old Trafford and rewarded his boss with another vital goal to edge United closer to a return to the Champions League.
Palace had taken an early lead at Old Trafford when Maxence Lacroix outmuscled Leny Yoro to guide in a header from Brennan Johnson’s corner.
But United hit back to remain unbeaten under Carrick and take their tally to 19 points from a possible 21.
The game swung on one incident as Lacroix was sent off and conceded a penalty for pulling back Matheus Cunha just before the hour mark.
Bruno Fernandes confidently stroked the resulting spot-kick past former team-mate Dean Henderson.
Fernandes was then the creator for the second as his curling cross was powered in by Sesko.
The Slovenian has now scored seven times in his last eight appearances to quieten critics of his £74 million ($100 million) price tag after a slow start to his career in England.
